Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD.
Identifieur interne : 000023 ( Main/Exploration ); précédent : 000022; suivant : 000024Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD.
Auteurs : Sunita Mulpuru [Canada] ; Li Li [Canada] ; Lingyun Ye [Canada] ; Todd Hatchette [Canada] ; Melissa K. Andrew [Canada] ; Ardith Ambrose [Canada] ; Guy Boivin [Canada] ; William Bowie [Canada] ; Ayman Chit [Canada] ; Gael Dos Santos ; May Elsherif [Canada] ; Karen Green [Canada] ; Francois Haguinet [Belgique] ; Scott A. Halperin [Canada] ; Barbara Ibarguchi [Canada] ; Jennie Johnstone [Canada] ; Kevin Katz [Canada] ; Joanne M. Langley [Canada] ; Jason Leblanc [Canada] ; Mark Loeb [Canada] ; Donna Mackinnon-Cameron [Canada] ; Anne Mccarthy [Canada] ; Janet E. Mcelhaney [Canada] ; Allison Mcgeer [Canada] ; Jeff Powis [Canada] ; David Richardson [Canada] ; Makeda Semret [Canada] ; Vivek Shinde [États-Unis] ; Daniel Smyth [Canada] ; Sylvie Trottier [Canada] ; Louis Valiquette [Canada] ; Duncan Webster [Canada] ; Shelly A. Mcneil [Canada]Source :
- Chest [ 1931-3543 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Broncho-pneumopathie chronique obstructive (épidémiologie), Canada (épidémiologie), Comorbidité, Facteurs de risque, Femelle, Grippe humaine (), Grippe humaine (épidémiologie), Hospitalisation (tendances), Humains, Indice de gravité médicale, Jeune adulte, Mâle, Pronostic, Sujet âgé, Taux de survie (tendances), Vaccination (), Vaccins antigrippaux (usage thérapeutique), Virus de la grippe A (immunologie), Études de suivi, Études prospectives, Évaluation des risques ().
- MESH :
- immunologie : Virus de la grippe A.
- tendances : Hospitalisation, Taux de survie.
- usage thérapeutique : Vaccins antigrippaux.
- épidémiologie : Broncho-pneumopathie chronique obstructive, Canada, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Comorbidité, Facteurs de risque, Femelle, Grippe humaine, Humains, Indice de gravité médicale, Jeune adulte, Mâle, Pronostic, Sujet âgé, Vaccination, Études de suivi, Études prospectives, Évaluation des risques.
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Canada (epidemiology), Comorbidity, Female, Follow-Up Studies, Hospitalization (trends), Humans, Influenza A virus (immunology), Influenza Vaccines (therapeutic use), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Male, Middle Aged, Prognosis, Prospective Studies, Pulmonary Disease, Chronic Obstructive (epidemiology), Risk Assessment (methods), Risk Factors, Severity of Illness Index, Survival Rate (trends), Vaccination (methods), Young Adult.
- MESH :
- chemical , therapeutic use : Influenza Vaccines.
- geographic , epidemiology : Canada.
- epidemiology : Influenza, Human, Pulmonary Disease, Chronic Obstructive.
- immunology : Influenza A virus.
- methods : Risk Assessment, Vaccination.
- prevention & control : Influenza, Human.
- trends : Hospitalization, Survival Rate.
- Adolescent, Adult, Aged, Comorbidity, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Severity of Illness Index, Young Adult.
Abstract
BACKGROUND
The effectiveness of influenza vaccination in reducing influenza-related hospitalizations among patients with COPD is not well described, and influenza vaccination uptake remains suboptimal.
METHODS
Data were analyzed from a national, prospective, multicenter cohort study including patients with COPD, hospitalized with any acute respiratory illness or exacerbation between 2011 and 2015. All patients underwent nasopharyngeal swab screening with polymerase chain reaction (PCR) testing for influenza. The primary outcome was an influenza-related hospitalization. We identified influenza-positive cases and negative control subjects and used multivariable logistic regression with a standard test-negative design to estimate the vaccine effectiveness for preventing influenza-related hospitalizations.
RESULTS
Among 4,755 hospitalized patients with COPD, 4,198 (88.3%) patients with known vaccination status were analyzed. The adjusted analysis showed a 38% reduction in influenza-related hospitalizations in vaccinated vs unvaccinated individuals. Influenza-positive patients (n = 1,833 [38.5%]) experienced higher crude mortality (9.7% vs 7.9%; P = .047) and critical illness (17.2% vs 12.1%; P < .001) compared with influenza-negative patients. Risk factors for mortality in influenza-positive patients included age > 75 years (OR, 3.7 [95% CI, 0.4-30.3]), cardiac comorbidity (OR, 2.0 [95% CI, 1.3-3.2]), residence in long-term care (OR, 2.6 [95% CI, 1.5-4.5]), and home oxygen use (OR, 2.9 [95% CI, 1.6-5.1]).
CONCLUSIONS
Influenza vaccination significantly reduced influenza-related hospitalization among patients with COPD. Initiatives to increase vaccination uptake and early use of antiviral agents among patients with COPD could reduce influenza-related hospitalization and critical illness and improve health-care costs in this vulnerable population.
TRIAL REGISTRY
ClinicalTrials.govNo.:NCT01517191; URL www.clinicaltrials.gov.
DOI: 10.1016/j.chest.2018.10.044
PubMed: 30616737
Affiliations:
- Belgique, Canada, États-Unis
- Ontario, Pennsylvanie, Québec
- Hamilton (Ontario), Montréal, Toronto
- Université McGill, Université McMaster, Université de Toronto
Links toward previous steps (curation, corpus...)
Le document en format XML
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Langley</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infectious Diseases, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Infectious Diseases, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name><affiliation wicri:level="1"><nlm:affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Health Sciences North Research Institute, Sudbury, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Mount Sinai Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><affiliation wicri:level="1"><nlm:affiliation>Toronto East General Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto East General Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><affiliation wicri:level="1"><nlm:affiliation>William Osler Health System, Brampton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>William Osler Health System, Brampton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, McGill University, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, McGill University, Montreal, QC</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, King of Prussia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name><affiliation wicri:level="1"><nlm:affiliation>The Moncton Hospital, Moncton, NB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Moncton Hospital, Moncton, NB</wicri:regionArea><wicri:noRegion>NB</wicri:noRegion></affiliation></author><author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec, Quebec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name><affiliation wicri:level="1"><nlm:affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Sherbrooke, Sherbrooke, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name><affiliation wicri:level="1"><nlm:affiliation>Horizon Health, Saint John, NB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Horizon Health, Saint John, NB</wicri:regionArea><wicri:noRegion>NB</wicri:noRegion></affiliation></author><author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30616737</idno><idno type="pmid">30616737</idno><idno type="doi">10.1016/j.chest.2018.10.044</idno><idno type="wicri:Area/Main/Corpus">000024</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000024</idno><idno type="wicri:Area/Main/Curation">000024</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000024</idno><idno type="wicri:Area/Main/Exploration">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD.</title><author><name sortKey="Mulpuru, Sunita" sort="Mulpuru, Sunita" uniqKey="Mulpuru S" first="Sunita" last="Mulpuru">Sunita Mulpuru</name><affiliation wicri:level="1"><nlm:affiliation>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON, Canada. Electronic address: smulpuru@toh.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Hatchette, Todd" sort="Hatchette, Todd" uniqKey="Hatchette T" first="Todd" last="Hatchette">Todd Hatchette</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec, Quebec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Faculty of Medicine, Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Chit, Ayman" sort="Chit, Ayman" uniqKey="Chit A" first="Ayman" last="Chit">Ayman Chit</name><affiliation wicri:level="4"><nlm:affiliation>Sanofi Pasteur, Swiftwater, PA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Sanofi Pasteur, Swiftwater, PA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Dos Santos, Gael" sort="Dos Santos, Gael" uniqKey="Dos Santos G" first="Gael" last="Dos Santos">Gael Dos Santos</name><affiliation><nlm:affiliation>Business & Decision Life Sciences, Brussels, Belgium (GlaxoSmithKline).</nlm:affiliation><wicri:noCountry code="subField">Belgium (GlaxoSmithKline)</wicri:noCountry></affiliation></author><author><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Mount Sinai Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Haguinet, Francois" sort="Haguinet, Francois" uniqKey="Haguinet F" first="Francois" last="Haguinet">Francois Haguinet</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Wavre, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>GlaxoSmithKline, Wavre</wicri:regionArea><wicri:noRegion>Wavre</wicri:noRegion></affiliation></author><author><name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Ibarguchi, Barbara" sort="Ibarguchi, Barbara" uniqKey="Ibarguchi B" first="Barbara" last="Ibarguchi">Barbara Ibarguchi</name><affiliation wicri:level="1"><nlm:affiliation>GlaxoSmithKline, Mississauga, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>GlaxoSmithKline, Mississauga, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><affiliation wicri:level="1"><nlm:affiliation>North York General Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>North York General Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Langley, Joanne M" sort="Langley, Joanne M" uniqKey="Langley J" first="Joanne M" last="Langley">Joanne M. Langley</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infectious Diseases, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Infectious Diseases, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author><author><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><affiliation wicri:level="1"><nlm:affiliation>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name><affiliation wicri:level="1"><nlm:affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Health Sciences North Research Institute, Sudbury, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><affiliation wicri:level="1"><nlm:affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Mount Sinai Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><affiliation wicri:level="1"><nlm:affiliation>Toronto East General Hospital, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto East General Hospital, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><affiliation wicri:level="1"><nlm:affiliation>William Osler Health System, Brampton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>William Osler Health System, Brampton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, McGill University, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, McGill University, Montreal, QC</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, King of Prussia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>GlaxoSmithKline, King of Prussia</wicri:cityArea></affiliation></author><author><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name><affiliation wicri:level="1"><nlm:affiliation>The Moncton Hospital, Moncton, NB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>The Moncton Hospital, Moncton, NB</wicri:regionArea><wicri:noRegion>NB</wicri:noRegion></affiliation></author><author><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name><affiliation wicri:level="1"><nlm:affiliation>Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Hospitalier Universitaire de Québec, Quebec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name><affiliation wicri:level="1"><nlm:affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Université de Sherbrooke, Sherbrooke, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name><affiliation wicri:level="1"><nlm:affiliation>Horizon Health, Saint John, NB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Horizon Health, Saint John, NB</wicri:regionArea><wicri:noRegion>NB</wicri:noRegion></affiliation></author><author><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name><affiliation wicri:level="1"><nlm:affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS</wicri:regionArea><wicri:noRegion>NS</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chest</title><idno type="eISSN">1931-3543</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Canada (epidemiology)</term><term>Comorbidity</term><term>Female</term><term>Follow-Up Studies</term><term>Hospitalization (trends)</term><term>Humans</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (therapeutic use)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Prospective Studies</term><term>Pulmonary Disease, Chronic Obstructive (epidemiology)</term><term>Risk Assessment (methods)</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Survival Rate (trends)</term><term>Vaccination (methods)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Broncho-pneumopathie chronique obstructive (épidémiologie)</term><term>Canada (épidémiologie)</term><term>Comorbidité</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation (tendances)</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Taux de survie (tendances)</term><term>Vaccination ()</term><term>Vaccins antigrippaux (usage thérapeutique)</term><term>Virus de la grippe A (immunologie)</term><term>Études de suivi</term><term>Études prospectives</term><term>Évaluation des risques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Pulmonary Disease, Chronic Obstructive</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="tendances" xml:lang="fr"><term>Hospitalisation</term><term>Taux de survie</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Hospitalization</term><term>Survival Rate</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Broncho-pneumopathie chronique obstructive</term><term>Canada</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Prospective Studies</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Comorbidité</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Indice de gravité médicale</term><term>Jeune adulte</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Vaccination</term><term>Études de suivi</term><term>Études prospectives</term><term>Évaluation des risques</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The effectiveness of influenza vaccination in reducing influenza-related hospitalizations among patients with COPD is not well described, and influenza vaccination uptake remains suboptimal.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Data were analyzed from a national, prospective, multicenter cohort study including patients with COPD, hospitalized with any acute respiratory illness or exacerbation between 2011 and 2015. All patients underwent nasopharyngeal swab screening with polymerase chain reaction (PCR) testing for influenza. The primary outcome was an influenza-related hospitalization. We identified influenza-positive cases and negative control subjects and used multivariable logistic regression with a standard test-negative design to estimate the vaccine effectiveness for preventing influenza-related hospitalizations.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among 4,755 hospitalized patients with COPD, 4,198 (88.3%) patients with known vaccination status were analyzed. The adjusted analysis showed a 38% reduction in influenza-related hospitalizations in vaccinated vs unvaccinated individuals. Influenza-positive patients (n = 1,833 [38.5%]) experienced higher crude mortality (9.7% vs 7.9%; P = .047) and critical illness (17.2% vs 12.1%; P < .001) compared with influenza-negative patients. Risk factors for mortality in influenza-positive patients included age > 75 years (OR, 3.7 [95% CI, 0.4-30.3]), cardiac comorbidity (OR, 2.0 [95% CI, 1.3-3.2]), residence in long-term care (OR, 2.6 [95% CI, 1.5-4.5]), and home oxygen use (OR, 2.9 [95% CI, 1.6-5.1]).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Influenza vaccination significantly reduced influenza-related hospitalization among patients with COPD. Initiatives to increase vaccination uptake and early use of antiviral agents among patients with COPD could reduce influenza-related hospitalization and critical illness and improve health-care costs in this vulnerable population.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRY</b></p><p>ClinicalTrials.govNo.:NCT01517191; URL www.clinicaltrials.gov.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30616737</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>11</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1931-3543</ISSN><JournalIssue CitedMedium="Internet"><Volume>155</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>01</Month></PubDate></JournalIssue><Title>Chest</Title><ISOAbbreviation>Chest</ISOAbbreviation></Journal><ArticleTitle>Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD.</ArticleTitle><Pagination><MedlinePgn>69-78</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0012-3692(18)32725-9</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chest.2018.10.044</ELocationID><Abstract><AbstractText Label="BACKGROUND">The effectiveness of influenza vaccination in reducing influenza-related hospitalizations among patients with COPD is not well described, and influenza vaccination uptake remains suboptimal.</AbstractText><AbstractText Label="METHODS">Data were analyzed from a national, prospective, multicenter cohort study including patients with COPD, hospitalized with any acute respiratory illness or exacerbation between 2011 and 2015. All patients underwent nasopharyngeal swab screening with polymerase chain reaction (PCR) testing for influenza. The primary outcome was an influenza-related hospitalization. We identified influenza-positive cases and negative control subjects and used multivariable logistic regression with a standard test-negative design to estimate the vaccine effectiveness for preventing influenza-related hospitalizations.</AbstractText><AbstractText Label="RESULTS">Among 4,755 hospitalized patients with COPD, 4,198 (88.3%) patients with known vaccination status were analyzed. The adjusted analysis showed a 38% reduction in influenza-related hospitalizations in vaccinated vs unvaccinated individuals. Influenza-positive patients (n = 1,833 [38.5%]) experienced higher crude mortality (9.7% vs 7.9%; P = .047) and critical illness (17.2% vs 12.1%; P < .001) compared with influenza-negative patients. Risk factors for mortality in influenza-positive patients included age > 75 years (OR, 3.7 [95% CI, 0.4-30.3]), cardiac comorbidity (OR, 2.0 [95% CI, 1.3-3.2]), residence in long-term care (OR, 2.6 [95% CI, 1.5-4.5]), and home oxygen use (OR, 2.9 [95% CI, 1.6-5.1]).</AbstractText><AbstractText Label="CONCLUSIONS">Influenza vaccination significantly reduced influenza-related hospitalization among patients with COPD. Initiatives to increase vaccination uptake and early use of antiviral agents among patients with COPD could reduce influenza-related hospitalization and critical illness and improve health-care costs in this vulnerable population.</AbstractText><AbstractText Label="TRIAL REGISTRY">ClinicalTrials.govNo.:NCT01517191; URL www.clinicaltrials.gov.</AbstractText><CopyrightInformation>Copyright © 2018 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mulpuru</LastName><ForeName>Sunita</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON, Canada. Electronic address: smulpuru@toh.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Lingyun</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hatchette</LastName><ForeName>Todd</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrew</LastName><ForeName>Melissa K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ambrose</LastName><ForeName>Ardith</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boivin</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowie</LastName><ForeName>William</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chit</LastName><ForeName>Ayman</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sanofi Pasteur, Swiftwater, PA; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dos Santos</LastName><ForeName>Gael</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Business & Decision Life Sciences, Brussels, Belgium (GlaxoSmithKline).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>ElSherif</LastName><ForeName>May</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Green</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haguinet</LastName><ForeName>Francois</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline, Wavre, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halperin</LastName><ForeName>Scott A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ibarguchi</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline, Mississauga, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnstone</LastName><ForeName>Jennie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Katz</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>North York General Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langley</LastName><ForeName>Joanne M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>LeBlanc</LastName><ForeName>Jason</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loeb</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacKinnon-Cameron</LastName><ForeName>Donna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ottawa Hospital Research Institute, Clinical Epidemiology Program, University of Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElhaney</LastName><ForeName>Janet E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Health Sciences North Research Institute, Sudbury, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McGeer</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powis</LastName><ForeName>Jeff</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Toronto East General Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richardson</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>William Osler Health System, Brampton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Semret</LastName><ForeName>Makeda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Infectious Diseases, Faculty of Medicine, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shinde</LastName><ForeName>Vivek</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>GlaxoSmithKline, King of Prussia, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Moncton Hospital, Moncton, NB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trottier</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre Hospitalier Universitaire de Québec, Quebec, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valiquette</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Université de Sherbrooke, Sherbrooke, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Webster</LastName><ForeName>Duncan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Horizon Health, Saint John, NB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNeil</LastName><ForeName>Shelly A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Canadian Center for Vaccinology, IWK Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN)</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT01517191</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>FRN96974</GrantID><Agency>CIHR</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Chest</MedlineTA><NlmUniqueID>0231335</NlmUniqueID><ISSNLinking>0012-3692</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002170" MajorTopicYN="N" Type="Geographic">Canada</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="Y">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029424" MajorTopicYN="N">Pulmonary Disease, Chronic Obstructive</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COPD</Keyword><Keyword MajorTopicYN="Y">hospitalization</Keyword><Keyword MajorTopicYN="Y">influenza</Keyword><Keyword MajorTopicYN="Y">pulmonary</Keyword><Keyword MajorTopicYN="Y">vaccine effectiveness</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Lagace-Wiens</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Light</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poirier</LastName><ForeName>Andre</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Taylor</LastName><ForeName>Gregory</ForeName><Initials>G</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>10</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>1</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>1</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30616737</ArticleId><ArticleId IdType="pii">S0012-3692(18)32725-9</ArticleId><ArticleId IdType="doi">10.1016/j.chest.2018.10.044</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li><li>Canada</li><li>États-Unis</li></country><region><li>Ontario</li><li>Pennsylvanie</li><li>Québec</li></region><settlement><li>Hamilton (Ontario)</li><li>Montréal</li><li>Toronto</li></settlement><orgName><li>Université McGill</li><li>Université McMaster</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Dos Santos, Gael" sort="Dos Santos, Gael" uniqKey="Dos Santos G" first="Gael" last="Dos Santos">Gael Dos Santos</name></noCountry><country name="Canada"><noRegion><name sortKey="Mulpuru, Sunita" sort="Mulpuru, Sunita" uniqKey="Mulpuru S" first="Sunita" last="Mulpuru">Sunita Mulpuru</name></noRegion><name sortKey="Ambrose, Ardith" sort="Ambrose, Ardith" uniqKey="Ambrose A" first="Ardith" last="Ambrose">Ardith Ambrose</name><name sortKey="Andrew, Melissa K" sort="Andrew, Melissa K" uniqKey="Andrew M" first="Melissa K" last="Andrew">Melissa K. Andrew</name><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><name sortKey="Bowie, William" sort="Bowie, William" uniqKey="Bowie W" first="William" last="Bowie">William Bowie</name><name sortKey="Chit, Ayman" sort="Chit, Ayman" uniqKey="Chit A" first="Ayman" last="Chit">Ayman Chit</name><name sortKey="Elsherif, May" sort="Elsherif, May" uniqKey="Elsherif M" first="May" last="Elsherif">May Elsherif</name><name sortKey="Green, Karen" sort="Green, Karen" uniqKey="Green K" first="Karen" last="Green">Karen Green</name><name sortKey="Halperin, Scott A" sort="Halperin, Scott A" uniqKey="Halperin S" first="Scott A" last="Halperin">Scott A. Halperin</name><name sortKey="Hatchette, Todd" sort="Hatchette, Todd" uniqKey="Hatchette T" first="Todd" last="Hatchette">Todd Hatchette</name><name sortKey="Ibarguchi, Barbara" sort="Ibarguchi, Barbara" uniqKey="Ibarguchi B" first="Barbara" last="Ibarguchi">Barbara Ibarguchi</name><name sortKey="Johnstone, Jennie" sort="Johnstone, Jennie" uniqKey="Johnstone J" first="Jennie" last="Johnstone">Jennie Johnstone</name><name sortKey="Katz, Kevin" sort="Katz, Kevin" uniqKey="Katz K" first="Kevin" last="Katz">Kevin Katz</name><name sortKey="Langley, Joanne M" sort="Langley, Joanne M" uniqKey="Langley J" first="Joanne M" last="Langley">Joanne M. Langley</name><name sortKey="Leblanc, Jason" sort="Leblanc, Jason" uniqKey="Leblanc J" first="Jason" last="Leblanc">Jason Leblanc</name><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><name sortKey="Loeb, Mark" sort="Loeb, Mark" uniqKey="Loeb M" first="Mark" last="Loeb">Mark Loeb</name><name sortKey="Mackinnon Cameron, Donna" sort="Mackinnon Cameron, Donna" uniqKey="Mackinnon Cameron D" first="Donna" last="Mackinnon-Cameron">Donna Mackinnon-Cameron</name><name sortKey="Mccarthy, Anne" sort="Mccarthy, Anne" uniqKey="Mccarthy A" first="Anne" last="Mccarthy">Anne Mccarthy</name><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E" last="Mcelhaney">Janet E. Mcelhaney</name><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name><name sortKey="Mcneil, Shelly A" sort="Mcneil, Shelly A" uniqKey="Mcneil S" first="Shelly A" last="Mcneil">Shelly A. Mcneil</name><name sortKey="Powis, Jeff" sort="Powis, Jeff" uniqKey="Powis J" first="Jeff" last="Powis">Jeff Powis</name><name sortKey="Richardson, David" sort="Richardson, David" uniqKey="Richardson D" first="David" last="Richardson">David Richardson</name><name sortKey="Semret, Makeda" sort="Semret, Makeda" uniqKey="Semret M" first="Makeda" last="Semret">Makeda Semret</name><name sortKey="Smyth, Daniel" sort="Smyth, Daniel" uniqKey="Smyth D" first="Daniel" last="Smyth">Daniel Smyth</name><name sortKey="Trottier, Sylvie" sort="Trottier, Sylvie" uniqKey="Trottier S" first="Sylvie" last="Trottier">Sylvie Trottier</name><name sortKey="Valiquette, Louis" sort="Valiquette, Louis" uniqKey="Valiquette L" first="Louis" last="Valiquette">Louis Valiquette</name><name sortKey="Webster, Duncan" sort="Webster, Duncan" uniqKey="Webster D" first="Duncan" last="Webster">Duncan Webster</name><name sortKey="Ye, Lingyun" sort="Ye, Lingyun" uniqKey="Ye L" first="Lingyun" last="Ye">Lingyun Ye</name></country><country name="Belgique"><noRegion><name sortKey="Haguinet, Francois" sort="Haguinet, Francois" uniqKey="Haguinet F" first="Francois" last="Haguinet">Francois Haguinet</name></noRegion></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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